Small Business Server Anti-Virus Exclusions:

Exchange related Exclusions
Exchange Server Database = C:\Program Files\Exchsrvr\Mdbdata
Exchange MTA files = C:\Program Files\Exchsrvr\Mtadata
Exchange Message tracking log files = C:\Program Files\Exchsrvr\server_name.log
Exchange SMTP Mailroot = C:\Program Files\Exchsrvr\Mailroot
Exchange working files = C:\Program Files\Exchsrvr\Mdbdata
Site Replication Service (not normally used in SBS but should be excluded anyway) = C:\Program Files\Exchsrvr\srsdata C:\Program Files\Exchsrvr\Conndata

IIS related Exclusions
IIS System Files = C:\WINDOWS\system32\inetsrv
IIS Compression Folder = C:\WINDOWS\IIS Temporary Compressed Files

Domain Controller related exclusions
Active Directory database files = C:\WINDOWS\NTDS SYSVOL C:\WINDOWS\SYSVOL
NTFRS Database Files = C:\WINDOWS\ntfrs
Windows SharePoint Services Temporary SharePoint space = C:\windows\temp\Frontpagetempdir

Additional Exclusions
Removable Storage Database (used by SBS Backup) = C:\Windows\System32\ntmsdata
SBS POP3 connector Failed Mail = C:\Program Files\Microsoft Windows Small Business Server\Networking\POP3\Failed Mail
SBS POP3 connector Incoming Mail = C:\Program Files\Microsoft Windows Small Business Server\Networking\POP3\Incoming Mail
Windows Update Store = C:\WINDOWS\SoftwareDistribution\DataStore DHCP
Database Store = C:\WINDOWS\system32\dhcp WINS Database Store = C:\WINDOWS\system32\wins

Thanks to Wayne Small

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